Nucleus

The Open Developer Platform for Synthetic Cells

Ecosystem

Docs

Orchestrating complex work-flows with modular robotics to integrate design, assembly, and predictive modeling.

DevNotes

A platform for rapidly communicating bite-sized ideas and work.

Hub

A collaborative Jupyter environment pre-loaded with open-source digital tools for design and analysis.

Forum

Discussion, Q&A, and conversation around Nucleus and synthetic cell engineering.

Datasets

Sample microscopy datasets for compari-son and testing of large microscopy data-set viewing tools.

Launched in December 2023, Nucleus is an open platform for synthetic cells. It was developed to address the growing need for shared technologies required to advance the field and realize the vision of engineerable biology built from scratch.

What began as a focused effort among a few dedicated advocates has grown into a global community of more than 30 academic, industry, and government groups. b.next created Nucleus to address a critical requirement for interoperability across this research community; a network coordinated through accessible and useful tools can build more complex and effective cells than any laboratory working in isolation.

Nucleus Technology Platform

Nucleus is designed to operationalize the foundational components and capabilities being developed by the frontier synthetic cell community. Currently, many of these components are developed in isolation without shared design principles or common features, making them difficult to combine and build upon.

By standardizing these fundamental components on a single platform, integration and scale become possible. Nucleus provides an integrated approach to engineering through core capabilities designed to work together:

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Materials: Standardized biological and chemical components.

Protocols: Validated, reproducible laboratory procedures.

Documentation: Technical specifications and implementation guides.

Software: Tools for design, modeling, and analysis.

Explore Nucleus

Open Collaborative Development

Building and integrating synthetic cells as a community at scale requires fit-for-purpose infrastructure for collaboration. Nucleus includes digital infrastructure that enables researchers to easily design and analyze experiments in ways compatible with others as well as rapidly share learnings. These collaborative capabilities allow the global community to build on, engage with, and extend the platform's capacities collectively.

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To ensure the platform continues to serve the needs of the ecosystem, we invite you to read the independent Conscience report surveying the synthetic cell community and share your thoughts.

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